Her strategy won't work against Ann Wagner, Matt Blunt or Peter Kinder.
Peter Kinder is certainly capable of blowing a Senate race and Matt Blunt would probably lose by an Akin-level margin.
I feel that Ann Wagner or Peter Kinder could defeat Claire McCaskill by about 5% in 2018 because they are both pretty strong campaigners and don't come across as conservative extremists like Todd Akin did in 2012. I also feel that Matt Blunt could narrowly defeat McCaskill as well if 2018 turns out to be a bloodbath for the Democrats (very likely if Hillary Clinton wins in 2016) and/or if Democratic turnout in Missouri is low enough. Also, Matt Blunt hasn't been in office since 2009, so many people have already forgotten about his uneventful Gubernatorial term.