2006 and 2008 were insanely Democratic years. 2010(as of now) doesn't look like it will be.
Plus as Padfoot said, the controversy surronding her has died down somewhat. And as I said Portman will be running statewide and he used to pull percents in the 70's out of this district and I firmly expect his Senate totals in this district to match or exceed that. Unless his campaign collapses and he gives up of course.
I dont see Portman getting in the 70's in the district, but he should get around 65%.
I think it's possible. Even Blackwell and DeWine did very well in this part of the state while going do to big defeats statewide. (They are from the area, but so is Portman.)