Lugar could possibly retire, no? We would have a pretty strong House bench in the state by 2012.
Corker will probably win re-election handily, since there's no one to run against him and he hasn't been too much of a nutter.
Richard Lugar was so strong a candidate last time that the Democrats ran nobody against him. Age will eventually take him down, as it did with John Warner (R-VA), another well-respected Republican Senator.
Indiana is no longer a reliably right-wing state, and Lugar has typically run as a moderate. Should the GOP nominate a right-winger as a successor for Lugar, then Indiana stands to be a Democratic pick-up.