Possibly if a Democrat is elected in 2028
That was my first thought as well.
It actually would already have happened in 2020 if not for special elections. Neither McCain's nor Isakson's seat were up until 2022. So if they didn't die or resign for health reasons, Democrats wouldn't have been able to flip them, ergo Biden would have came in with a Democratic House and a 52 seat Republican majority in the senate.
A president coming in without a trifecta will probably lead to him/her having to run for reelection without any significant legislative accomplishments since there's much less bipartisanship as there was during the Nixon, Reagan or Bush sen. years. Depending on senate composition, the new president might even be forced to spend a ton of political capital early on just to get his cabinet confirmed, which usually should be a routine procedure.