I could see a Cuomo-Clinton ticket which actually would be quite similar to the Bartlett-Hoynes ticket in the West Wing. Northeastern intellectual Catholic liberal type with a centrist southern womanizing running mate.
They would lose.....Cuomo is an Italian and Bush would have played the ethnic card, he wouldn't have won any Southern states, even if he picked Clinton.....
Cuomo probably knew why he never ran for president, he never wanted to hear the stereotypes of mobs, etc.
And that stereotype (not helped by the trial that finally saw Teflon Don John Gotti locked away for good occurring during the primary season) wouldn't have been just a Bush thing (in real life, there was a mini-scandal when one of the answering machine tapes released by Gennifer Flowers showed both Flowers and Clinton discussing a possibly Cuomo candidacy in terms that seemed to strongly imply they believed that Cuomo - based solely on his being a New York politician of Italian descent - was at minimum on friendly terms with the Mafia).