I think DeSantis is positioning himself to run from Trump's right based on what I'm seeing as of late. I think Trump is favored, but only slightly and DeSantis is the one candidate that can beat him, and would have better odds against Biden/Harris than Trump would.
Ron DeSantis I think could win every state except California, Hawaii, Washington, Illinois, Maryland, New York, Massachusetts, Delaware, and Vermont if he was the Republican nominee. He might even get a 47 state sweep in 2028 in his reelection bid. I would say that Glenn Youngkin would be the best running mate for Ron DeSantis.