She'll draw a liberal challenger who generates a lot of online buzz and raises a considerable amount of money, but Sinema still wins the primary by >40pts in the end.
She then goes on to lose the GE when Ron DeSantis defeats Kamala Harris in the first popular vote majority for the GOP since 2004 (AZ goes for DeSantis by >5pts)
This almost certainly isn't going to happen, even if Republicans narrowly win the PV (which is unlikely, but possible.) Sinema could lose in the event of AZ going Republican by about 2%, though.