I don't see Senate Democrats abolishing the filibuster (at least not in the 117th Congress), and I don't see HR1 getting through the Senate while the filibuster is in place.
But I suppose one can hope that enough Senate Republicans would sign on to pass a watered-down version of the bill. I don't think we're going to get nationwide independent commissions, but many of the other reforms seem like they could be on the table.
Fitzpatrick had some compromise bill up recently which did include some HR 1 stuff. However I don't expect D's to compromise after DC statehood.