A Republican as dependent on working class voters as Trump is not winning reelection, if he is only winning Indiana by 6% to 8%. That is worse than Romney's performance and he did much better with college educated whites at that.
What is happening then? Is he just collapsing completely in white educated suburbia? That's the only explanation if this is real.
I can tell you that Republicans are collapsing in white, educated greater Indy. At every level of government. The only thing that keeps Indiana safely red is all the WWC voters the GOP picked up over the last ten years. If educated while voters voted like they do now back in 2008, Obama would have won Indiana by 5 to 10 points.
Basically, Indiana (see also Texas) is becoming more of a microcosm of America. Note well that Donald Trump offends well-educated people who despise an anti-intellectualism that rips at something that makes many people what they are. Trump's anti-intellectualism goes far beyond poking wayward college professors to insulting such people as schoolteachers, research scientists, accountants, engineers, and medical professionals who aren't in their positions for supplying original and daring thought. Well-educated white people see themselves having more in common with the black bourgeoisie (the "Talented Tenth" of the time of Booker T. Washington's day has since become at the least the "Talented Third"), Asian-Americans, and middle-class Hispanics than with semi-literate white people.
Mitt Romney appealed more to conservative, pro-business economics (taxes, spending, regulation); Trump appeals more to a low-brow culture for its resentments of such people as the schoolteacher who disparaged someone's bad grammar in school.
Note also that early voting makes voting far easier than in usual years. Election-day voting ends at 6PM local time, which explains why Indiana is usually an early call.