Uncle Joe Biden is still very active in Democratic politics and cancer research. In fact, the Democratic Party will be likely taking a road traveled by Joe Biden to attract populism. In many ways, the '24 elections will vindicate Biden's retail populism over Obama's intellectual technocracy, as '20 did. Expect Joe to be very happy in 2025. Joe Biden is the unsung hero of this saga.
Near-prescience, perhaps?
If you think about it, Biden pretty much checks off the qualities that TD listed for a realigning President to have: older, extensive experience in elected office, suffered several electoral defeats, and is from the same region as the foreshadowing President (he represented DE obviously in the Senate but is from PA and is culturally Midwestern).