Trump cannot win the popular vote, he'd probably do worse than in 2020.
Desantis could though it's too early to tell. He could win the southern states by even bigger margins than usual (FL+15, TX +10, MS+25, AL+30 etc.) and also cut the d margin in blue states (New York +15, CA +20, VI +5 etc). That would mean a very inefficient vote distribution though.
What's VI?
Presumably referring to Virginia with the wrong abbreviation?
VI is normally the Virgin Islands, and they don't get to vote in presidential elections.