Yeah.
There are a few ways.
He could get an establishment opponent if he's controversial in certain ways.
If he governs as a typical Republican, he might have a challenger from his wing calling him a sellout.
If he's too moderate in office, he might have a far-right opponent from the Cruz wing.
All are possible.
But if he's personally popular, he will not have a primary. Trump's surprising showing is the reason Pat Toomey and Ron Johnson were re-elected. The only reason. He's the reason Kelly Ayotte almost made it back. He's the reason Scott Young upset Evan Bayh. Principle be damned, incumbent Republicans are not going to sabotage a President they think is popular and will help their re-election chances.