Perhaps indirectly, in the same way that Wilhelm II is responsible for Stalin. Sure, he's a link in the chain, but the rise of ISIS was hardly *inevitable* from his actions. Instability in general could be more heavily attributed to him, and even then there's caveats that complicate things. There's been ample chance for the course to have been diverted since then, and by that I don't mean undoing all the damage, but it's like a asteroid. The further away it is, the less of a push you have to give it to avoid it hitting a very specific spot.
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