No, it's never again going to be in our self-interest as a country.
People need to understand the history here. Isolationism wasn't an altruistic policy for the United States. At the beginning of the country, we wanted open markets in Europe and we didn't have the military power to meddle. (I also would ask the Native Americans on the trail of tears if we were all that isolationist) So, our ploy to being able to trade with both England and France was to assert that we were uninterested in foreign affairs. At the same time, we also wanted to protect our infant industrial sector with protectionist policies. That was American self-interest and explained by isolationism. The simple fact is that weak, undeveloped countries are suited to isolationism, while strong, developed countries are suited to imperialism.
Bingo.
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