Aside from Allentown, yes.
Well, South Bethlehem has a large Latino population, but anyways.
The Lehigh Valley has nice scenery as Phil said, but I found the area when I lived there very boring. You have the inner Valley itself which is just, as one of Billy Joel's songs says, miles and miles of parking space or rusting steel mills and other factories. In that mix you have a few colleges such as Lehigh, Lafayette, and Moravian which have a quaint feel to them. South bethlehem is a weird mix of college students, white retirees, and a recent influx of Latinos from NYC. The area Phil's referring to is south of the Lehigh Valley over South Mountain which I remember as the Saucon Valley and one of the towns is Center Valley which would probably be BRTD's hell on earth.
Politically, I would imagine the Valley more Democratic as I remembered more O'Brien and Gore signs back in 2000 while I saw more Toomey and Bush signs in the more exurban/suburban Saucon Valley. I guess you could call the Saucon Valley exurban Philly/NYC and the suburban Allentown/Behtlehem. That said, I would say the Lehigh Valley is an eclectic mix of every ideology. It really depends on the local/national climate from year to year. As much as Pat Toomey could win it, so could a far more liberal candidate and in certain elections, more liberal candidates such as Kerry, Obama, and Rendell have also won.