On a serious note, I think he looks a lot "healthier" than Biden for a variety of obvious reasons why probably works in his favor. I think his main flaw would be he borders on being fat and while usually he's wearing a suit that sort of covers up his physique, he's probably bound to strip down to a button up on much of the campaign trail.
Yes, looks can have subtle impacts.
DeSantis definitely would benefit from losing some weight, but he looks much worse in a suit. He looks fairly obese in his suits while just a bit chunky in casual attire.
Compare this
https://images.app.goo.gl/tXwKjBc3nmsBGNGo9 to this
https://images.app.goo.gl/WCtRUsvazjunFLqd7