Entirely dependent on 2022. Slotkin is in a Trump district, so I'd say she's certainly an underdog for reelection. Stevens's race is tilt D for 2022 and is probably the frontrunner to replace Stabenow in 2024, assuming she wins in '22.
Not necessarily. Slotkin's district may become bluer in the redistricting cycle, though that's not necessary as it has an Indpendent Redistricting Commission that's strictly nonpartisan. And as Cookie Damage (D-NJ) already pointed out, Slotkin's district, while still voting red, shifted visibly leftward from 2016.