True enough but if (say) the North East region of England were to break away, based on who holds the Westminster seats at the moment, something like 90% would be held by one party.
Well, parties do tend to (in the long run) adjust themselves to the countries they're in (on the national level). If you imposed the US Party system on the UK, the Democrats would always win...to a point where either the Republicans would move left or the Democratic party would fracture.
You can even see this on the local level, on occasion...Phil Bredesen (D-TN) is probably more conservative than Arnold Schwarzenegger (R-CA).
So, if the Northeast were to split off, Labour would have the immediate advantage...but I doubt Labour could actually keep itself intact for that long without external threats.