Good ad, but I think calling out his hypocrisy can help too. That ad with clips of him bashing Trump and heaping praise on Biden was gold because it shows what a snake he is. Part of the reason he's vulnerable is that no side trusts him: The moderates/independents who used to like him hate that he's gone full MAGA, and true believers still think he's a two-faced rat who would stab Trump in the back if he thought he had to. This could result in depressed GOP base turnout for him (wouldn't be surprised if a lot of Trump voters leave the Senate line blank), increased Democratic turnout against him, and swing voters turning on him.
Plus, no one likes someone who's as blatant about his hypocrisy as Graham has been. The guy swore that he wouldn't do exactly what he's doing right now on the SCOTUS seat and dared people to use it against him. Now that they are, he literally went on Fox and cried, begging for money because people hate him and his opponent is outraising him. Also not a good look.
Literally nobody in Washington disgusts me more than Lindsey Graham, not even Trump himself. He's a sniveling little weasel who doesn't even try to hide it. He's so arrogant he thinks he can get away with being such a bald-faced liar in plain sight, then acts surprised and breaks down when the polls are tight and he's getting outraised. He doesn't deserve to be even competitive in this seat, and there would be nothing more satisfying than to see this hypocrite go down because he hitched his wagon to a man he once said was so awful his party deserved to lose for nominating him.