No. Just look at other counties in and around Appalachia (Southern WV, Southeast KY, Southwest PA) that voted for Gore and then turned red. They never never came back. Biden is less hated than Hillary (the real reason why Bernie underperformed in 2020 - many of his 2016 voters were just protesting Hillary) but he's not going to reverse the underlying trend.
This doesn't seem to be quite right - the southern bits of the Kentucky coalfield voted for Gore but then swung to Bush and never came back, but much of the northern end voted for Bush in 2000 then swung back to Kerry in 2004.
Poll
