I've never been, but from what I know about the place it seems like a sinister, eldritch hive of late-century uncontrollable neoliberal Sun Belt sprawl sucking the mosquito-ridden life out of the mushy, swampy earth and the oppressive humid air, battered by hurricanes, drenched in ugly Gulf Coast heat, and lacking in culture. The fact that lean (the drug) was invented there makes me think that it must be truly awful for its denizens to indulge in such a noxious, cloying, sticky mess in order to escape the pains of living there.
That seems to correct to this former Houston resident (though thankfully my tenure was quite short).