It's a safe bet that he'll underperform 2018 in a Biden midterm, but without knowing what demos are most likely to defect or stay home under Biden, this kind of exercise is going to be very hard. This all depends on how numbers look in two weeks but also in what the major news stories that drive activism in the Biden term look like.
Pritzker will be a two term governor and afterwards Presidential nominee in 2028 if Biden loses in 2024.
Pritzker won't get anywhere near the Presidential nomination in his life. Every year he waits the party base will become more unfavorable for him.