No, though President Grant shouldn't be on it either. Put someone like Coolidge on there.
I agree they should put Reagan on the fifty, and create a new one like $75 with Coolidge on it.
Really, they should start printing bills over $100 again. A dollar now is worth much less than it was in 1969, such that someone actually using a larger bill isn't so implausible.
Absent credit cards, big bills would indeed be much more common now due to inflation. But I use a credit card whenever possible, and thus can get by with 20 dollar bills in general.
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