Cultural or science usually. Maybe one of the others if a viable path exists.
I tried to get into Civ6 a few months ago and it just didn't grab me. Felt like a total conversion mod for Civ5 that's still in Beta. I would like to give it another shot some time though.
That was me with Civ5. You had to buy all the extensions in order to be able to have all the functionalities and stuff you had in Civ4. I figured I had better stuff to do with my money so I just continued playing Civ4 instead.
Civ4 was the best Civilization game imo. The only things I preferred with Civ5 were the quality of the graphics and the larger offer of civilizations.
I've never, ever played Civ6.