I know Obama had proposed a financial package to try and address the problem of attracting jobs to a region no employers are interested in, but the Rs in Congress chose to ignore it (even with all the goodies included in the great compromise), and Hillary has proposed an even bigger package, but I don't know why the Rs would go for that either. I don't know how effective it would be, but in the interim, each year that goes by the region will get older, poorer, probably more drug addled and more dead.
They wouldn't. If they had a Republican in the White House who could claim credit for it
(as the people benefiting from it would give most of the credit to basically whoever was in the white house, as is usual), and had a reasonable belief that such a financial package would benefit them politically, they would probably do some sort of relief. Otherwise, if the poor, drug addicted citizens will continue voting for them, it's irrelevant. I don't say this necessarily out of bias against the GOP, but because they showed no desire to help the American people in the middle of the recession. No compromise on infrastructure spending to create jobs/help economy, almost all Republicans voted against the stimulus, etc.
If they wouldn't help America in general then, I can't see why they would help Appalachia now unless there were political dividends to be had.