No, I don't think so, especially since last year's upset. The best scenario for Dems long-term I see is a 1980 redux: Challenger beats unpopular incumbent president, whose party controlled the WH for only fours and came in as an outsider, and then the new president gets reelected four years later. In 2028, the sitting vice president gets elected and wins a third term for his party, but then loses reelection to a more moderate opposition.
While I see your Reagan-Bush-Clinton analogy, you also have to remember that the nation was already realigned
ideologically, meaning that despite a Democrat being able to come to power a mere 12 years later, said Dem could only do so under the terms of the Reagan Realignment.
Assuming 2020 is the Dems' 1980, perhaps said Dem will have moved the nation enough to the left that the Republican could only run slightly to the right of Eisenhower in order to win significantly.