How many Safe-R suburban seats of major cities are there remaining?
Depending on how broadly you define 'suburban', plausibly dozens? I live in a Safe R (eh, Likely R for a 2018 type of environment) suburban seat, OH-7, and it's not in some particularly historically Republican metropolitan area like Phoenix. (The reverse, actually). This is not that strange of a seat type.
That's not really a solely suburban seat because it's backed by lots of rural areas too strengthening it's R numbers a lot, so possibly he's excluding seats like that...but if so that arguably applies to this one too.