Probably. I don't see the Republicans getting a super-majority in the Senate within the next 10 years
Could they defend through reconciliation?
Perhaps, but I don't see that happening either.
With Obama in office he'll probably only approve very small changes (workweek back to 40 hours, medical device tax repeal with very small cuts, etc.) if the GOP takes the Senate 2015-2017 for "muh bipartisanship", but if the GOP gains the White House in 2017 there will be some major overhauls. I give repeal only a very small chance, even if the Republicans control the WH/Senate/House trifecta unless they tread very, very carefully.