Yes, if there is someone from PA on the GOP ticket. You could get a favorite son effect.
I think if that would happen, Obama would win reelection.
But that won't happen. Ridge? No pro-choicers need apply. Santorum? Just no. There are at least a dozen other more politically relevent choices available to appease social conservatives, and Santorum's performance in the primaries isn't about to change that calculus. Toomey? Meh, a far outside shot maybe notwithstanding his recent election since he served a few terms in the House, but unless the sole goal of the nominee's Veep choice is "to maximize my shot at PA" there's just no compelling reason to pick him over at least a dozen other more prominent conservatives.
I think that depends on who the nominee is. I would say, however, that Ridge, Toomey, Santorum, and Corbett could be that person. BTW, there was no "compelling" reason to choose Biden (except he'd help in PA). And, for political "odd couples," Reagan/Bush.
That is the only way I could see Obama losing PA, while winning OH.