How about Indianapolis or Bakersfield, CA?
Most of the Republican-voting parts of Indianapolis are decidedly not urban and wouldn't even part of the city if it wasn't for the expansion to all of Marion County thing. From what I gathered from my time there, the nickname "Circle City" is only used to apply to the area within the I-485 /74 loop. So if you limit to those areas, the only Republican-voting areas are some suburban precincts on the outer southern edge, and an area in the northeast that looks like
this.
There is however a notably strong McCain precinct near the middle completely surrounded by strong D precincts I'm curious about.