And as for Sarah Jama: I can't rule out the likelihood of her losing; but by that measure, Joel Harden should have been a goner upon nomination to Ottawa Centre in '18--and he was reelected by a landslide in '22. (He also might have been Stiles' likeliest viable leadership opponent on the left, had he not been reprimanded by acting leader Peter Tabuns for perceived anti-Semitic statements)
FYI: Joel Harden announced he would not seek the ONDP leadership for personal reasons, long before that brouhaha about his perceived anti-Semitic comments.
I suspect the NDP will easily hold Hamilton Centre. Its a much much more NDP seat than Ottawa Centre is and the NDP has a new leader who is about 100 times more appealing than Horwath was. Also, the Liberals have to deal with a tarnished brand both provincially and federally. Running the same grade Z candidate who was squashed like a bug in 2018 is not the way i would imagine a Liberal upset win there would happen. They'd have to come up with some "supernova" of a candidate - and Deirdre Pike is more of a smouldering ember