DeSantis is clearly favored, and Fried is clearly a weaker candidate than Crist, who has now been a candidate in four statewide elections (two for Senate, two for Governor), and has run as a Republican, Independent, and Democrat. I'm thinking a DeSantis victory by an ~5-8% margin is the most logical outcome at this point.
That seems a bit high. I think that is his margin in a 2024 GE for president, but he seems much more likely to do worse in 2022 than 2024 all things being equal. It is much easier to come up with Florida Republican leaning voters who would prefer him over Biden/Harris, but wish they had a different Republican as governor than Democrats or others who like him as governor but want a Democrat as president. Those may have existed in the summer and fall of 2020, but this summer and spring likely has wiped out his crossover appeal. Not merely on policy but on tone.
Crist is weak as a retread. But he is a bit dangerous insofar as Crist/Bush Republicans are likely the constituency most likely to make the difference between a 49-48 Desantis loss and a 52-46 win.
The problem for Democrats is that the swing voters for anything less than a DeSantis 6 point win are Republicans who probably in a generic race favor a Republican for Governor.
In short, I think DeSantis has much deeper support than generic R but I think there is a lot of evidence that he no longer has broader support than generic Florida R.