Obama will struggle in Florida, Ohio (relative to Clinton), the South (which any Democrat will lose anyway. He runs better in Oregon and Washington.
His problem area in Ohio will be white blue collar workers. That is where race will rear its ugly head.
I don't think Obama will really do worse than Clinton or any other Democrat in the south. Black turnout would be higher for Obama than with Clinton or the others, and the white vote in parts of the south is already so solidly GOP its hard to imagine all that much could make it more GOP than it already is.