Not a First Lady, but someone very close to one.
Suzanne Perrin, the second wife of FDR, Jr., is still alive. She's 102.
Actually she died in December 2022, aged 101. Read her
obit here. It's very much a walk through history to imagine someone this connected to FDR (or just an old-school NYC socialite) was still with us only a year ago.
I once gamed-out an Alt History where Dewey wins 1948, and the Dems nominate FDR Jr. to win back the White House in 1952. He becomes a JFK-type figure, assassinated in 1955. Perrin was his young wife at the time, so ITTL her life after the White House would have totaled an astonishing 68 years (for comparison, Rosalyn Carter's was only 42.)