Honestly, him getting sidelined for like six weeks when the trial actually happens may be more significant than any reaction to the actual charges. If he gets indicted now, he'd be on trial likely at the end of 2023/start of 2024, at the height of the primaries. Imagine if he can't go to IA/NH/NV/SC because he's stuck in Manhattan at his court appearances every day.
Interesting angle…part of why Mayor Pete did well in Iowa and New Hampshire is because Sanders/Warren/Klobuchar were stuck in the impeachment trials.