Wisconsin: Likely R -> Tossup
US Senate: Tossup -> Lean D
I doubt it'll impact anything. Ron's always been the type to say crazy things but that didn't stop him from outperforming Trump. Russ was better.
Tbf, in 2016 Ron Johnson was relatively undefined and basically ran a slightly more friendly version of Trump's populist's campaign. Over the past 4 years he's shown his true colours though. For many moderates and conservatives who may have voted for Clinton, he was still an accpetable conservative to vote for.
In 2016, Johnson saw very significant crossover voting support in many suburbs, particularly around Milwaukee, which he probably won't get in 2022. That alone (probably) isn't enough to knock him off but will be notable.
Overall though he has been pretty effective at dodging these sorts of controversies who for a lot of other people would be a death kiss. Despite a lot of the things he says, he is quite a smart campaigner and messenger.