Stop with the Great Society overstuffed agendas and present everything one by one in simple barebones legislation. If Republicans want to filibuster the "Stop Pouring Toxic Waste into Children's Drinking Water" act then let them die on that hill; don't give them an easy out by sneaking solar panel funding into it. That goes for about everything that Democrats have been trying to pass in my lifetime. And, when something is clearly DOA, give up on it immediately. If Obama had realized the public option was dead and given up on it 6 months sooner, he would've saved himself a lot of trouble, and the same can be said about Biden and the Build Back Better drama.
Also, drop all social issues. Embrace the "No black America, no white America . . ." line of thinking from Obama's first campaign and go for a personal freedom, freedom of choice angle when it comes to these issues. All they really need to do is pass basic anti-discrimination laws, but other than that we don't need to hear about any of it.
Basically the 1992 campaign.