Tbf for the GOP, is there really much of a benefit to winning the Senate in 2022 beyond stopping Biden from confirming anymore justices to courts? Even if they somehow end up with just 48 seats in a worse case scenario, Biden will still control the White House and the Senate will almost surely flip R in 2024 when they actually have a chance to control the Pres.
Also rmbr the next time this Senate map will be up is in 2028, a Presidential year, which by nature will likely be more stable no matter who wins overall. Any flips the GOP make this cycle would be very vulnerable come 2028, especially since states like AZ and GA seem to generally be getting bluer.
If they get down to 48 then it becomes an open question as to whether the filibuster is retained. Of course, dems may not bother with it if they still lose the house in this world, and we can argue all day whether Feinstein/King/Kelly/Tester/Kaine/Casey/Shaheen/Hassan would actually do it if they were the deciding vote, but at least the possibility for its elimination is there. And with the possible exception of eliminating the Hyde Amendment, that would allow Democrats to pass their full legislative menu through the Senate.
