Wyoming is unlikely because I think the two seats represented by Ds are significant Native areas.
There’s also the point that both Wyoming, a very urban mountain state, and Massachusetts, a pretty catholic white ethnic state, are trending towards being more competitive, not less.
Zaybay has already shown that, if anything, the opposite is true for Massachusetts’ trend, but this is also a very odd way to frame its political demographics. The reason that it is so D, and not going to change anytime soon, is that it is the most college-educated state in the nation, and a fairly secular one (IIRC, Boston shockingly actually has one of the lowest % of practising Catholics of any of the historically white ethnic major cities).
This is a relatively new development. Throughout the later half of the 20th century, Boston was considered the most socially conservative of the big Northeastern cities, largely because of the Catholic Church's influence. The priest molestation scandals significantly diminished the Church's prestige and credibility there. I would say that it is probably the most secular of the Northeastern cities now.