I think the GOP would what to avoid that. Basically every time a senator tries to reclaimed their seat it never ends well (Feingold 2016), since it makes the politician look too power hungry
I think the environment would be a lot different. Here you have a well known and well liked former senator (to Republicans that is). She would already have the fundraising networks and name ID. not to mention in the general she would be a shoe-in, not because of any real skill she has, but as she proved in 2014 she ca ride a wave