Presumably, per the ruling in
Seila Law, the specific challenge coming this year will not strike down the law. I imagine the law will be gradually struck down over the course of the next five years or so, though.
It would be hilarious if Republicans gave Democrats a big brilliant talking point to hit them with again and again, and then they don't even end up having a chance at getting a gain from the lawsuit.
It is overwhelming conventional wisdom on the GOP side that campaigning on repealing Obamacare/healthcare policy generally helps them as a party, and it's kind of hard to look at the record of the 2010s elections without suspecting there is something quite substantial to that idea.