End of Chevron deference, resurrection of the non-delegation doctrine, maybe overturning Auer v. Robbins — it's abortion and civil rights that get the headlines, but the top priority for these people is ending effective federal regulation of... everything
I'm not sure ending Chevron deference would be an easy task. Justice Thomas joined the pro-Chevron majority in the last big case on the issue that I can think of,
City of Arlington v. FCC and the dissent was relatively tame (as expected by Roberts) in its denunciation. The court also declined to hear Baldwin v. US last year, a case which anti-Chevron people thought would be a good vehicle to seriously damage or get rid of it. I personally dislike Chevron and believe it allows too much discretion to basically unchecked federal agencies, but I don't think the doctrine is going anywhere anytime soon.