I don't think Trump would run against an incumbent Biden in 2012, because a lot of his actions in 2012 and 2016 were motivated by racism against Obama.
If Trump does win the nomination...
Biden's stimulus policies, and lack of willingness to remove troops from Iraq hurt him. In addition his IRL opposition to killing Osama Bin Laden, means he probably wouldn't have sanctioned the SEAL Team Six mission to kill him.
President Joe Biden/Vice President Barack Obama 268 Electoral Votes 50% of the Popular Vote
Businessman Donald Trump/Senator Jim DeMint 270 Electoral Votes 49% of the Popular Vote.