Likely D.
Can Arizona Republicans ask her to step aside and find a better replacement?
Who else could they get? Arpaio? Ward? Biggs? Gosar? Aside from Ducey and Yee, Arizona's Republican bench is really poor for a state that was red until very recently.
If it was left to party insiders at a nominating convention, perhaps Jeff Flake might have a chance (whereas he wouldn't have a hope in a standard primary, even against McSally). There are also a couple of other elected Republican statewide officials - would Brnovich or Hart be credible?
They could also try to bring back Jan Brewer. Part of the reason AZ's R bench seems weak is because they've been brutal in dispensing with Republican incumbents.