Yes. I think there should be 150 senators with 50 from each state being up for election every 2 years. The first 50 in the first year, The next 50 after that, and the final 50 after that. Afterwards, cycle it again.
Damn, I came her to post exactly this. It's always bothered me how in any given year 15% of the states (and up to 30-40% of the population depending on which cycle) have no say in a full branch of government.
Alternately I could see having Class I and II at four year terms, and making it 200--the second set determined by popular vote proportion (though that might start getting too bloated and I have no idea how you'd go about listing the party's slate)