I'm sure it's been done before but I just whipped up a whole batch of 'em on DRA. Idea is that senate seats are not statewide, instead each state is divided into two equally populous districts. In this scenario, congressional committees are put in charge of drawing all the districts, and a lot of horse trading takes place...
Alabama - the south is a longshot Democrat district, probably at least Likely R, and the north would be safe for Senator Roy Moore.
Arkansas both East and West are Safe R
Arizona Not a good map for Democrats pre-Trump. The Inner district could elect Sinema post-Trump, while the outer district will become better for Republicans.
California No attempt at partisanship here, just SoCal vs. the rest. This is very good for the former, as both OTL senators are Bay Area giants.
Colorado Inner district Democratic, Outer district Republican but could fall in a landslide thanks to Boulder County.
Connecticut Both districts Democrat
Florida North is solidly R, while the South is generally D but could easily be taken by Rubio in a wave.
Georgia Gerrymandered to force an even map. "Outer" district solidly R, "Inner" district for Democrats.
Iowa Democrats in the East, Republicans in the West (which includes Des Moines).
Illinois Easy to allow Republican seat, just keep Cook whole in the Metro district and the downstate district will lean rightward.
Indiana Combining Indy and the northeast creates a swing seat, alongside a Safe R East/South seat.
Kansas Eastern seat is less safe, especially after Trump, but still fairly conservative.
Kentucky I probably could make an east/west map but I didn't feel like it. North/South works fine, given how the rural east has been trending for a long time. North is probably still Safe R, but it's enough to get people's hopes up.
Louisana East/West divide, both Safe R.
Massachusetts East/West divide, both Safe D, probably could be better but my priority was making sure the southeast doesn't mess around in the west's primaries.
Maryland This one turned out nicely. The Outer seat is a Lean R seat, while the Inner seat is a well packed black plurality 80% Dem seat.
Michigan Inner seat is Safe D, Outer Seat could be won by a Democrat in OTL 2012 but not after Trump.
Missouri Combining St. Louis and Columbia in the eastern seat is the best Democrats can do to defend McCaskill. West is Safe R.
Mississippi Hideous map, but for good reason: West district is the only black majority seat nationwide. East seat, of course, is Safe R.
North Carolina No gerrymandering here, Lean D (east) and Likely R (west).
North Dakota No reason to bother with anything other than a simply east/west split. Heidi might survive in the east, or might not.
Nebraska Democrat gerrymander so they might win the Inner/East seat.
New Jersey South winnable for Republicans but is Lean D, North is Safe D.
New Mexico Went with metro/non metro split here.
Nevada The only way to split Nevada in the 21st century.
New York Because none of Long or Staten Island can be separated from the downstate seat, the upstate seat includes most of the Bronx. As such, both Safe D.
Ohio tried to do both an east/west split and a north/south split, but it makes since given the placements of Cleveland and Cincinnati. Northeast seat should be secure for Brown, despite Trump and some conservative areas. Southwest, despite Columbus, should be secure for Portman.
Oklahoma Safe R
Oregon Northwest is Safe D, outer seat is Tossup.
Pennslyvania Dem East, GOP West. Pittsburgh is inevitably screwed.
South Carolina South is probably Lean R but winnable, North is Safe R.
South Dakota East is somewhat winnable in a pre-Trump Democratic wave.
Tennessee West is clearly more moderate.
Texas Democratic gerrymander so they can win the South, which includes Houston, Austin, El Paso, and the Rio Grande valley. Ted Cruz is doomed. North is Safe R.
Utah Metro is winnable post-Trump.
Vermont West Sanders, East Safe D.
Virginia Not a favorite of mine, I guess you could call it an R gerrymander. Very important for me, if probably inconsequential, that Loundoun county is in the R seat to block it from having in nominating a senate Democrat.
Washington Like in Oregon, one seat is Safe D and the other is competitive.
Wisconsin Southern Dems, North Reps, clean and simple.
West Virginia whatever
Wyoming