If a convention proposed an amendment that repealed & replaced the entirety of the Constitution, then the stipulation that "no State, without its Consent, shall be deprived of its equal suffrage in the Senate" can be gotten around, either with the new Constitution stipulating that neither the Senate in its current form nor the Article V Senate clause are repealed in the new Constitution (in which case, the new Constitution would still get to come into effect upon only 3/4ths of the states ratifying it); or with all 50 states approving the new Constitution (much easier said than done, of course, though still required if the new Constitution chooses to keep neither the Senate nor the Article V Senate clause); or legal acceptance of an argument to be made that, if the new Constitution abolished the Senate, then no state could technically have been "deprived" of its "equal suffrage" in a Senate that doesn't exist.
That may be solid grounds for legal secession. Is that not breach of contract? Or do individual states even exist as semi-sovereign entities? Could a national, general plebiscite agree to abolish the current Constitution and adopt a new one?
Article XIII (or whatever) This Constitution shall supersede and nullify any previous Constitutions upon winning a 3/4 majority in an election open to all citizens of the United States, both natural born and naturalized.
I mean, this happens in other countries as a regular thing, but we've never gone through it.