I find it hard to believe Democrats could win this district, given that, unlike PA-18, it doesn't have any history of supporting Democratic candidates at really any level.
That being said, if Tipirneni somehow does pull off an upset, holy crap are we in for a tsunami in November.
You'd be surprised. Lesko has a reputation for being an idiot (with one article likening her to Betsy DeVos, ye gods and little fishies) and she's currently wrapped up in a pretty deep-running money laundering scandal, for which Tipirneni has been absolutely blasting her.
There's a window here. It's a very small one, but after Alabama and Pennsylvania, I leave nothing out of the question.