The more interesting question might be if he wins Nassau and Suffolk counties and Staten Island.
I'd say no for Nassau but don't know about the other two.
Nassau county no, Staten Island & Suffolk are possiblle athough I would say still would lean towards Spitzer (will be fairly close). A Weld type candidate could do decent here, Golisano would rip into his margins upstate (due to social conservatives).
Either way Spitzer is unbeatable so it doesn't really matter at this point. However a problem the Republicans run into is ithe differences within their own ranks in different parts of the state. A socially moderate to liberal Republican can do decently in Staten Island, Westchester & Long Island, but would have some issues from upstate conservatives if someone like Golisano ran on a 3rd party. They run a more mainline conservative to appease the upstate Republicans than the downstate Republicans (Long Island, Westchester & Staten Island) flee towards the Dems