Might be worth bumping this thread...
If John McCain beats Hillary Clinton, we may also see a realignment election, except this one will likely favor the GOP.
If Hillary won, would we see a realignment in favor of Democrats?
Unless she is a highly successful President who will end the War in Iraq without any major consequences, pass immigration reform without antagonizing working class, and convince 60 Senators to pass her health care plan, I can't see how see could oversee an alignment in American politics.